Target theses
Evidence-traced assessments — including the honest empties
Each thesis commits to a verdict and traces every claim to the graph. Filter by non-consensus strength: the strong-angle theses are the showcase; the “honest empty” ones are the trust signal.
Where Mosaic found a strong angle
The rest of the range
CHEK1No strong angle
Kinase
Genetically bulletproof, clinically stuck — and the two facts are linked.
Read thesisIDH1No strong angle
Metabolic enzyme (neomorphic gain-of-function)
A validated, approved target that the genetic-dependency lens completely misses.
Read thesisKRASModerate non-consensus angle
GTPase
A validated oncogene addiction in the middle of a patent gold-rush.
Read thesisMYCNo strong angle
Transcription factor
The most-validated, least-druggable target in this set — and the gap is the thesis.
Read thesisPTENNo strong angle
Tumor suppressor
A tumor suppressor — the wrong shape for an inhibitor program, and the graph says so.
Read thesis